D21A (p.Asp21Ala) variant of TP53 (Cellular tumor antigen p53)
D21A (p.Asp21Ala) in TP53 (Cellular tumor antigen p53) is a missense change. Clinical records from ClinVar and UniProt describe it as likely benign in the context of Hereditary cancer-predisposing syndrome. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes experimental measurements and structural context.
D21A (p.Asp21Ala) variant details
- p.Asp21Ala
- Ensembl rs2151047348
- Likely benign
- Hereditary cancer-predisposing syndrome
- Missense
- Variant Prioritization Score for Impact Estimate 0.417
- ESM-1b 0.27
- AlphaMissense 0.15
- ClinVar: Likely benign (Hereditary cancer-predisposing syndrome)
- UniProt: Likely benign
- Structural context available
- p53 variant effect measured by cell growth: score -3.41