S35C (p.Ser35Cys) variant of TCF7L2 (Transcription factor 7-like 2)
S35C (p.Ser35Cys) in TCF7L2 (Transcription factor 7-like 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.58 / 1. The record also includes population frequency data and structural context.
S35C (p.Ser35Cys) variant details
- p.Ser35Cys
- ExAC rs776204265
- TOPMed rs776204265
- gnomAD rs776204265
- Missense
- Variant Prioritization Score for Impact Estimate 0.582
- CADD 24.40
- PolyPhen-2 0.92
- SIFT 0.07
- Most common in the REMAINING population (allele frequency 3.3e-05)
- Structural context available