S20C (p.Ser20Cys) variant of TCF7L2 (Transcription factor 7-like 2)
S20C (p.Ser20Cys) in TCF7L2 (Transcription factor 7-like 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.66 / 1. The record also includes population frequency data and structural context.
S20C (p.Ser20Cys) variant details
- p.Ser20Cys
- gnomAD rs1456854681
- Missense
- Variant Prioritization Score for Impact Estimate 0.66
- CADD 26.60
- PolyPhen-2 0.97
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 9.1e-07)
- Structural context available