L12I (p.Leu12Ile) variant of TCF7L2 (Transcription factor 7-like 2)
L12I (p.Leu12Ile) in TCF7L2 (Transcription factor 7-like 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.65 / 1. The record also includes population frequency data and structural context.
L12I (p.Leu12Ile) variant details
- p.Leu12Ile
- Ensembl rs2030733334
- Missense
- Variant Prioritization Score for Impact Estimate 0.646
- CADD 24.80
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9.1e-07)
- Structural context available