K22Q (p.Lys22Gln) variant of TCF7L2 (Transcription factor 7-like 2)
K22Q (p.Lys22Gln) in TCF7L2 (Transcription factor 7-like 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.59 / 1. The record also includes population frequency data, published literature, and structural context.
K22Q (p.Lys22Gln) variant details
- p.Lys22Gln
- gnomAD 10-112950820-A-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.586
- CADD 23.20
- PolyPhen-2 0.42
- SIFT 0.11
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available