G7S (p.Gly7Ser) variant of TCF7L2 (Transcription factor 7-like 2)
G7S (p.Gly7Ser) in TCF7L2 (Transcription factor 7-like 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.77 / 1. The record also includes population frequency data and structural context.
G7S (p.Gly7Ser) variant details
- p.Gly7Ser
- cosmic curated COSV10887
- gnomAD rs1294078020
- Missense
- Variant Prioritization Score for Impact Estimate 0.767
- CADD 28.10
- PolyPhen-2 1.00
- SIFT 0.04
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available