G6V (p.Gly6Val) variant of TCF7L2 (Transcription factor 7-like 2)
G6V (p.Gly6Val) in TCF7L2 (Transcription factor 7-like 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.76 / 1. The record also includes population frequency data, published literature, and structural context.
G6V (p.Gly6Val) variant details
- p.Gly6Val
- gnomAD 10-112950773-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.76
- CADD 27.30
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available
- Literature evidence available