G6S (p.Gly6Ser) variant of TCF7L2 (Transcription factor 7-like 2)
G6S (p.Gly6Ser) in TCF7L2 (Transcription factor 7-like 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.63 / 1. The record also includes population frequency data and structural context.
G6S (p.Gly6Ser) variant details
- p.Gly6Ser
- gnomAD rs1437908566
- Missense
- Variant Prioritization Score for Impact Estimate 0.625
- CADD 23.30
- PolyPhen-2 0.81
- SIFT 0.83
- Most common in the Non-Finnish European population (allele frequency 9.2e-07)
- Structural context available