E28G (p.Glu28Gly) variant of TCF7L2 (Transcription factor 7-like 2)
E28G (p.Glu28Gly) in TCF7L2 (Transcription factor 7-like 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.66 / 1. The record also includes population frequency data, published literature, and structural context.
E28G (p.Glu28Gly) variant details
- p.Glu28Gly
- gnomAD 10-112950839-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.661
- CADD 32.00
- PolyPhen-2 0.67
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available