P695L (p.Pro695Leu) variant of STAT3 (P40763)

P695L (p.Pro695Leu) in STAT3 (P40763) is a missense change. Clinical records from ClinVar and UniProt describe it as pathogenic/likely pathogenic in the context of Hyper-IgE recurrent infection syndrome 1, autosomal dominant; STAT3 gain of func. The record also includes structural context.

P695L (p.Pro695Leu) variant details