G127D (p.Gly127Asp) variant of STAT3 (P40763)
G127D (p.Gly127Asp) in STAT3 (P40763) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.59 / 1. The record also includes population frequency data and structural context.
G127D (p.Gly127Asp) variant details
- p.Gly127Asp
- Ensembl rs2144896420
- Missense
- Variant Prioritization Score for Impact Estimate 0.594
- REVEL 0.49
- CADD 22.20
- PolyPhen-2 0.30
- SIFT 0.62
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available