E100K (p.Glu100Lys) variant of STAT3 (P40763)
E100K (p.Glu100Lys) in STAT3 (P40763) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.50 / 1. The record also includes population frequency data and structural context.
E100K (p.Glu100Lys) variant details
- p.Glu100Lys
- cosmic curated COSV52894
- Missense
- Variant Prioritization Score for Impact Estimate 0.504
- REVEL 0.33
- CADD 22.60
- PolyPhen-2 0.12
- SIFT 0.59
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available