C108Y (p.Cys108Tyr) variant of STAT3 (P40763)
C108Y (p.Cys108Tyr) in STAT3 (P40763) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.74 / 1. The record also includes population frequency data and structural context.
C108Y (p.Cys108Tyr) variant details
- p.Cys108Tyr
- ExAC rs780604324
- gnomAD rs780604324
- Missense
- Variant Prioritization Score for Impact Estimate 0.745
- REVEL 0.72
- CADD 24.20
- PolyPhen-2 0.99
- SIFT 0.32
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available