V67L (p.Val67Leu) variant of SOS2 (Son of sevenless homolog 2)
V67L (p.Val67Leu) in SOS2 (Son of sevenless homolog 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.48 / 1. The record also includes population frequency data and structural context.
V67L (p.Val67Leu) variant details
- p.Val67Leu
- gnomAD rs1418008191
- Missense
- Variant Prioritization Score for Impact Estimate 0.476
- REVEL 0.45
- MetaLR 0.52
- MetaSVM 0.02
- CADD 23.00
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available