T66I (p.Thr66Ile) variant of SOS2 (Son of sevenless homolog 2)
T66I (p.Thr66Ile) in SOS2 (Son of sevenless homolog 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.64 / 1. The record also includes population frequency data and structural context.
T66I (p.Thr66Ile) variant details
- p.Thr66Ile
- gnomAD rs1886594420
- Missense
- Variant Prioritization Score for Impact Estimate 0.645
- REVEL 0.61
- MetaLR 0.70
- MetaSVM 0.48
- CADD 25.10
- PolyPhen-2 0.91
- SIFT 0.00
- Most common in the East Asian population (allele frequency 0.00019)
- Structural context available