S44P (p.Ser44Pro) variant of SOS2 (Son of sevenless homolog 2)
S44P (p.Ser44Pro) in SOS2 (Son of sevenless homolog 2) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.56 / 1. The record also includes population frequency data and structural context.
S44P (p.Ser44Pro) variant details
- p.Ser44Pro
- NCI-TCGA Cosmic COSV9936
- cosmic curated COSV99365
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.556
- REVEL 0.57
- MetaLR 0.44
- MetaSVM -0.18
- CADD 23.70
- PolyPhen-2 0.16
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available