R20W (p.Arg20Trp) variant of SOS2 (Son of sevenless homolog 2)
R20W (p.Arg20Trp) in SOS2 (Son of sevenless homolog 2) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.73 / 1. The record also includes population frequency data and structural context.
R20W (p.Arg20Trp) variant details
- p.Arg20Trp
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.729
- REVEL 0.75
- MetaLR 0.57
- MetaSVM 0.20
- CADD 33.00
- PolyPhen-2 0.70
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9.5e-07)
- Structural context available