I141T (p.Ile141Thr) variant of SOS2 (Son of sevenless homolog 2)
I141T (p.Ile141Thr) in SOS2 (Son of sevenless homolog 2) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.83 / 1. The record also includes population frequency data and structural context.
I141T (p.Ile141Thr) variant details
- p.Ile141Thr
- rs1378958999
- NCI-TCGA Cosmic COSV5357
- cosmic curated COSV53573
- gnomAD rs1378958999
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.833
- REVEL 0.95
- MetaLR 0.84
- MetaSVM 0.88
- CADD 27.00
- PolyPhen-2 1.00
- SIFT 0.02
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available