V107L (p.Val107Leu) variant of SOS1 (Son of sevenless homolog 1)
V107L (p.Val107Leu) in SOS1 (Son of sevenless homolog 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.49 / 1. The record also includes population frequency data and structural context.
V107L (p.Val107Leu) variant details
- p.Val107Leu
- gnomAD rs1235907251
- Missense
- Variant Prioritization Score for Impact Estimate 0.494
- REVEL 0.32
- AlphaMissense 0.56
- MetaLR 0.45
- MetaSVM -0.29
- CADD 21.80
- PolyPhen-2 0.27
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available