P7S (p.Pro7Ser) variant of SOS1 (Son of sevenless homolog 1)
P7S (p.Pro7Ser) in SOS1 (Son of sevenless homolog 1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data and structural context.
P7S (p.Pro7Ser) variant details
- p.Pro7Ser
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.403
- REVEL 0.20
- CADD 21.00
- PolyPhen-2 0.01
- SIFT 0.80
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 3.2e-05)
- Structural context available