L23P (p.Leu23Pro) variant of SOS1 (Son of sevenless homolog 1)
L23P (p.Leu23Pro) in SOS1 (Son of sevenless homolog 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.69 / 1. The record also includes population frequency data and structural context.
L23P (p.Leu23Pro) variant details
- p.Leu23Pro
- cosmic curated COSV67675
- Missense
- Variant Prioritization Score for Impact Estimate 0.694
- REVEL 0.81
- CADD 27.90
- PolyPhen-2 0.94
- SIFT 0.00
- Population evidence available
- Structural context available