L103S (p.Leu103Ser) variant of SOS1 (Son of sevenless homolog 1)
L103S (p.Leu103Ser) in SOS1 (Son of sevenless homolog 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.82 / 1. The record also includes population frequency data and structural context.
L103S (p.Leu103Ser) variant details
- p.Leu103Ser
- gnomAD rs1188721742
- Missense
- Variant Prioritization Score for Impact Estimate 0.824
- REVEL 0.96
- CADD 27.30
- PolyPhen-2 1.00
- SIFT 0.02
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available