W99* (p.Trp99Ter) variant of SLC22A8 (Organic anion transporter 3)
W99* (p.Trp99Ter) in SLC22A8 (Organic anion transporter 3) is a protein-truncating change. Clinical records from UniProt describe it as variant assessed as somatic; high impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.85 / 1. The record also includes population frequency data and structural context.
W99* (p.Trp99Ter) variant details
- p.Trp99Ter
- NCI-TCGA Cosmic COSV1002
- cosmic curated COSV10026
- TOPMed rs928963210
- gnomAD rs928963210
- Variant assessed as somatic; high impact.
- Stop Gained
- Variant Prioritization Score for Impact Estimate 0.85
- CADD 37.00
- UniProt: Variant assessed as somatic; high impact.
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available