V21L (p.Val21Leu) variant of SLC22A8 (Organic anion transporter 3)
V21L (p.Val21Leu) in SLC22A8 (Organic anion transporter 3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.09 / 1. The record also includes population frequency data and structural context.
V21L (p.Val21Leu) variant details
- p.Val21Leu
- ExAC rs747832381
- TOPMed rs747832381
- gnomAD rs747832381
- Missense
- Variant Prioritization Score for Impact Estimate 0.092
- REVEL 0.07
- MetaLR 0.08
- MetaSVM -1.06
- CADD 0.25
- PolyPhen-2 0.02
- SIFT 0.11
- Most common in the Latino/Admixed American population (allele frequency 2.3e-05)
- Structural context available