V21I (p.Val21Ile) variant of SLC22A8 (Organic anion transporter 3)
V21I (p.Val21Ile) in SLC22A8 (Organic anion transporter 3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.09 / 1. The record also includes population frequency data and structural context.
V21I (p.Val21Ile) variant details
- p.Val21Ile
- rs747832381
- NCI-TCGA Cosmic COSV6032
- cosmic curated COSV60324
- ExAC rs747832381
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.0916
- REVEL 0.07
- MetaLR 0.07
- MetaSVM -1.07
- CADD 0.21
- PolyPhen-2 0.06
- SIFT 0.15
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available