S4L (p.Ser4Leu) variant of SLC22A8 (Organic anion transporter 3)
S4L (p.Ser4Leu) in SLC22A8 (Organic anion transporter 3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
S4L (p.Ser4Leu) variant details
- p.Ser4Leu
- ESP rs146789686
- ExAC rs146789686
- TOPMed rs146789686
- gnomAD rs146789686
- Missense
- Variant Prioritization Score for Impact Estimate 0.231
- REVEL 0.12
- MetaLR 0.14
- MetaSVM -0.98
- CADD 16.70
- PolyPhen-2 0.21
- SIFT 0.01
- Most common in the Latino/Admixed American population (allele frequency 6.5e-05)
- Structural context available