N81S (p.Asn81Ser) variant of SLC22A8 (Organic anion transporter 3)
N81S (p.Asn81Ser) in SLC22A8 (Organic anion transporter 3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.49 / 1. The record also includes population frequency data and structural context.
N81S (p.Asn81Ser) variant details
- p.Asn81Ser
- rs774027900
- NCI-TCGA Cosmic COSV6032
- cosmic curated COSV60326
- ExAC rs774027900
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.492
- REVEL 0.41
- MetaLR 0.57
- MetaSVM -0.29
- CADD 23.40
- PolyPhen-2 0.98
- SIFT 0.05
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available