L114F (p.Leu114Phe) variant of SLC22A8 (Organic anion transporter 3)
L114F (p.Leu114Phe) in SLC22A8 (Organic anion transporter 3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.50 / 1. The record also includes population frequency data and structural context.
L114F (p.Leu114Phe) variant details
- p.Leu114Phe
- ExAC rs781123967
- gnomAD rs781123967
- Missense
- Variant Prioritization Score for Impact Estimate 0.502
- REVEL 0.60
- MetaLR 0.45
- MetaSVM -0.07
- CADD 25.00
- PolyPhen-2 1.00
- SIFT 0.03
- Most common in the Latino/Admixed American population (allele frequency 6.5e-05)
- Structural context available