I135T (p.Ile135Thr) variant of SLC22A8 (Organic anion transporter 3)
I135T (p.Ile135Thr) in SLC22A8 (Organic anion transporter 3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.50 / 1. The record also includes population frequency data and structural context.
I135T (p.Ile135Thr) variant details
- p.Ile135Thr
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.499
- REVEL 0.44
- MetaLR 0.48
- MetaSVM -0.07
- CADD 20.80
- PolyPhen-2 0.03
- SIFT 0.06
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available