H15R (p.His15Arg) variant of SLC22A8 (Organic anion transporter 3)
H15R (p.His15Arg) in SLC22A8 (Organic anion transporter 3) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as likely benign in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
H15R (p.His15Arg) variant details
- p.His15Arg
- rs1325562303
- ClinGen CA380990420
- ClinVar RCV004451352
- TOPMed rs1325562303
- Likely benign
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.296
- REVEL 0.10
- MetaLR 0.03
- MetaSVM -0.97
- CADD 1.37
- PolyPhen-2 0.00
- SIFT 1.00
- ClinVar: Likely benign (not specified)
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the African/African-American population (allele frequency 7.2e-05)
- Structural context available