G98D (p.Gly98Asp) variant of SLC22A8 (Organic anion transporter 3)
G98D (p.Gly98Asp) in SLC22A8 (Organic anion transporter 3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.77 / 1. The record also includes population frequency data and structural context.
G98D (p.Gly98Asp) variant details
- p.Gly98Asp
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.768
- REVEL 0.83
- MetaLR 0.75
- MetaSVM 0.67
- CADD 24.30
- PolyPhen-2 0.99
- SIFT 0.04
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available