W25R (p.Trp25Arg) variant of SFTPB (P07988)
W25R (p.Trp25Arg) in SFTPB (P07988) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.08 / 1. The record also includes population frequency data and structural context.
W25R (p.Trp25Arg) variant details
- p.Trp25Arg
- rs1320815322
- NCI-TCGA Cosmic COSV6089
- cosmic curated COSV60893
- gnomAD rs1320815322
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.0834
- REVEL 0.09
- CADD 0.00
- PolyPhen-2 0.00
- SIFT 0.83
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available