Y121C (p.Tyr121Cys) variant of REN (Renin)
Y121C (p.Tyr121Cys) in REN (Renin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data and structural context.
Y121C (p.Tyr121Cys) variant details
- p.Tyr121Cys
- gnomAD rs1410855329
- Missense
- Variant Prioritization Score for Impact Estimate 0.399
- REVEL 0.37
- MetaLR 0.38
- MetaSVM -0.23
- CADD 27.80
- PolyPhen-2 0.96
- SIFT 0.05
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available