T21S (p.Thr21Ser) variant of REN (Renin)
T21S (p.Thr21Ser) in REN (Renin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data and structural context.
T21S (p.Thr21Ser) variant details
- p.Thr21Ser
- TOPMed rs1420333399
- gnomAD rs1420333399
- Missense
- Variant Prioritization Score for Impact Estimate 0.165
- REVEL 0.05
- MetaLR 0.08
- MetaSVM -1.02
- CADD 9.63
- PolyPhen-2 0.01
- SIFT 0.46
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available