S74F (p.Ser74Phe) variant of REN (Renin)
S74F (p.Ser74Phe) in REN (Renin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
S74F (p.Ser74Phe) variant details
- p.Ser74Phe
- cosmic curated COSV10505
- 1000Genomes rs536696119
- ExAC rs536696119
- TOPMed rs536696119
- Missense
- Variant Prioritization Score for Impact Estimate 0.296
- REVEL 0.04
- MetaLR 0.09
- MetaSVM -0.95
- CADD 18.40
- PolyPhen-2 0.08
- SIFT 0.07
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available