S155G (p.Ser155Gly) variant of REN (Renin)
S155G (p.Ser155Gly) in REN (Renin) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
S155G (p.Ser155Gly) variant details
- p.Ser155Gly
- rs1558244998
- ClinGen CA344339249
- ClinVar RCV002745501
- TOPMed rs1558244998
- Uncertain significance
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.236
- REVEL 0.13
- MetaLR 0.13
- MetaSVM -0.95
- CADD 15.20
- PolyPhen-2 0.02
- SIFT 0.03
- ClinVar: Uncertain significance (not provided)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Latino/Admixed American population (allele frequency 6.5e-05)
- Structural context available