R6S (p.Arg6Ser) variant of REN (Renin)
R6S (p.Arg6Ser) in REN (Renin) is a missense change. Clinical records from EBI and UniProt describe it as likely benign. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data and structural context.
R6S (p.Arg6Ser) variant details
- p.Arg6Ser
- gnomAD rs1392033638
- Likely benign
- Missense
- Variant Prioritization Score for Impact Estimate 0.177
- REVEL 0.20
- MetaLR 0.10
- MetaSVM -1.06
- CADD 8.43
- PolyPhen-2 0.00
- SIFT 0.03
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available