P40S (p.Pro40Ser) variant of REN (Renin)
P40S (p.Pro40Ser) in REN (Renin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
P40S (p.Pro40Ser) variant details
- p.Pro40Ser
- TOPMed rs1436346379
- gnomAD rs1436346379
- Missense
- Variant Prioritization Score for Impact Estimate 0.344
- REVEL 0.23
- MetaLR 0.15
- MetaSVM -0.94
- CADD 24.80
- PolyPhen-2 0.82
- SIFT 0.03
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available