P25L (p.Pro25Leu) variant of REN (Renin)
P25L (p.Pro25Leu) in REN (Renin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data and structural context.
P25L (p.Pro25Leu) variant details
- p.Pro25Leu
- ExAC rs761487063
- TOPMed rs761487063
- gnomAD rs761487063
- Missense
- Variant Prioritization Score for Impact Estimate 0.211
- REVEL 0.14
- MetaLR 0.09
- MetaSVM -1.05
- CADD 22.20
- PolyPhen-2 0.01
- SIFT 0.07
- Most common in the REMAINING population (allele frequency 8.3e-05)
- Structural context available