L12M (p.Leu12Met) variant of REN (Renin)
L12M (p.Leu12Met) in REN (Renin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
L12M (p.Leu12Met) variant details
- p.Leu12Met
- gnomAD rs1456036182
- Missense
- Variant Prioritization Score for Impact Estimate 0.243
- REVEL 0.16
- MetaLR 0.16
- MetaSVM -0.96
- CADD 22.30
- PolyPhen-2 0.73
- SIFT 0.06
- Most common in the South Asian population (allele frequency 2.3e-05)
- Structural context available