L120P (p.Leu120Pro) variant of REN (Renin)
L120P (p.Leu120Pro) in REN (Renin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.52 / 1. The record also includes population frequency data and structural context.
L120P (p.Leu120Pro) variant details
- p.Leu120Pro
- gnomAD rs1352971146
- Missense
- Variant Prioritization Score for Impact Estimate 0.519
- REVEL 0.46
- MetaLR 0.31
- MetaSVM -0.42
- CADD 32.00
- PolyPhen-2 0.98
- SIFT 0.03
- Most common in the Ashkenazi Jewish population (allele frequency 3.9e-05)
- Structural context available