K139R (p.Lys139Arg) variant of REN (Renin)
K139R (p.Lys139Arg) in REN (Renin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
K139R (p.Lys139Arg) variant details
- p.Lys139Arg
- TOPMed rs1658227637
- Missense
- Variant Prioritization Score for Impact Estimate 0.345
- REVEL 0.12
- MetaLR 0.11
- MetaSVM -1.03
- CADD 14.60
- PolyPhen-2 0.00
- SIFT 0.13
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available