I90T (p.Ile90Thr) variant of REN (Renin)
I90T (p.Ile90Thr) in REN (Renin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.71 / 1. The record also includes population frequency data and structural context.
I90T (p.Ile90Thr) variant details
- p.Ile90Thr
- cosmic curated COSV65817
- ExAC rs772001785
- gnomAD rs772001785
- Missense
- Variant Prioritization Score for Impact Estimate 0.708
- REVEL 0.82
- MetaLR 0.67
- MetaSVM 0.69
- CADD 28.20
- PolyPhen-2 1.00
- SIFT 0.01
- Most common in the Latino/Admixed American population (allele frequency 2.3e-05)
- Structural context available