G142R (p.Gly142Arg) variant of REN (Renin)
G142R (p.Gly142Arg) in REN (Renin) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.47 / 1. The record also includes population frequency data and structural context.
G142R (p.Gly142Arg) variant details
- p.Gly142Arg
- NCI-TCGA Cosmic COSV6581
- cosmic curated COSV65817
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.472
- REVEL 0.37
- MetaLR 0.38
- MetaSVM -0.10
- CADD 23.30
- PolyPhen-2 0.84
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available