R187C (p.Arg187Cys) variant of RELA (Transcription factor p65)
R187C (p.Arg187Cys) in RELA (Transcription factor p65) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data and structural context.
R187C (p.Arg187Cys) variant details
- p.Arg187Cys
- NCI-TCGA Cosmic COSV5801
- cosmic curated COSV58013
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.511
- REVEL 0.27
- CADD 33.00
- PolyPhen-2 0.99
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available