R21L (p.Arg21Leu) variant of RBM10 (RNA-binding protein 10)
R21L (p.Arg21Leu) in RBM10 (RNA-binding protein 10) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data, experimental measurements, and structural context.
R21L (p.Arg21Leu) variant details
- p.Arg21Leu
- gnomAD rs1934465408
- Missense
- Variant Prioritization Score for Impact Estimate 0.342
- REVEL 0.15
- CADD 25.10
- PolyPhen-2 0.93
- SIFT 0.01
- Most common in the HGDP:FRENCH population (allele frequency 0.019)
- Structural context available
- RBM10 Zinc finger, RanBP2-type domain domainome 1.0: score -0.926