R21H (p.Arg21His) variant of RBM10 (RNA-binding protein 10)
R21H (p.Arg21His) in RBM10 (RNA-binding protein 10) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data, experimental measurements, and structural context.
R21H (p.Arg21His) variant details
- p.Arg21His
- NCI-TCGA Cosmic COSV6131
- cosmic curated COSV61312
- gnomAD rs1934465408
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.326
- REVEL 0.12
- CADD 25.10
- PolyPhen-2 0.96
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 8.8e-05)
- Structural context available
- RBM10 Zinc finger, RanBP2-type domain domainome 1.0: score -0.926