R15C (p.Arg15Cys) variant of RBM10 (RNA-binding protein 10)
R15C (p.Arg15Cys) in RBM10 (RNA-binding protein 10) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data, experimental measurements, and structural context.
R15C (p.Arg15Cys) variant details
- p.Arg15Cys
- NCI-TCGA Cosmic COSV6131
- cosmic curated COSV61310
- Ensembl rs2147127747
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.397
- REVEL 0.17
- CADD 27.40
- PolyPhen-2 0.35
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 0.00031)
- Structural context available
- RBM10 Zinc finger, RanBP2-type domain domainome 1.0: score 0.0337