D25G (p.Asp25Gly) variant of RBM10 (RNA-binding protein 10)
D25G (p.Asp25Gly) in RBM10 (RNA-binding protein 10) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data, experimental measurements, and structural context.
D25G (p.Asp25Gly) variant details
- p.Asp25Gly
- NCI-TCGA Cosmic COSV1002
- cosmic curated COSV10023
- Ensembl rs2147128171
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.288
- REVEL 0.10
- CADD 23.70
- PolyPhen-2 0.24
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 2.9e-05)
- Structural context available
- RBM10 Zinc finger, RanBP2-type domain domainome 1.0: score -0.15