L66V (p.Leu66Val) variant of RAG1 (P15918)
L66V (p.Leu66Val) in RAG1 (P15918) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
L66V (p.Leu66Val) variant details
- p.Leu66Val
- gnomAD rs1377826874
- Missense
- Variant Prioritization Score for Impact Estimate 0.249
- REVEL 0.13
- MetaLR 0.21
- MetaSVM -0.89
- CADD 11.80
- PolyPhen-2 0.04
- SIFT 0.36
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available